Violence has flared between Israeli forces and Palestinians protesting at Donald Trump's contentious recognition of Jerusalem as Israel's capital; BBC reported.
Clashes erupted in the occupied West Bank and over the Israeli-Gaza border, and there were scuffles in Jerusalem.
More than 200 Palestinians were hurt, Palestinian medical sources said.
Tensions are high in the wake of Mr Trump's announcement. His policy shift was hailed by Israel but condemned across the Arab and Islamic world.
Western allies of the US have also disavowed the move, which reversed decades of US neutrality on the status of Jerusalem.
Israel has always regarded Jerusalem as its capital, while the Palestinians said East Jerusalem - occupied by Israel in the 1967 war - as the capital of a future Palestinian state.
In recognising Jerusalem as Israel's capital, the US became the first country to do so since the foundation of the state in 1948.
Where has there been violence?
In the West Bank, Israeli forces clashed with Palestinians in the cities of Bethlehem, Ramallah, Hebron and Nablus, as well as smaller locations.
Television pictures from Bethlehem showed water cannon or so-called skunk water being used against stone-throwing protesters.
Clouds of tear gas and thick, black smoke from burning tyres filled the air. There were also reports of rubber bullets being fired by troops.
Similar scenes were reported in other places where there were confrontations.
Extra police were deployed in East Jerusalem ahead of the planned protests
Israel had deployed extra battalions to the West Bank in anticipation of violence after Palestinian leaders called for protests after Friday prayers.
In East Jerusalem there were scuffles as police pushed back hundreds of demonstrators outside the Old City. The ancient walled area, containing contentious holy sites, is historically a flashpoint for violence.
At least 217 Palestinians were wounded in the confrontations in the West Bank and East Jerusalem, Palestinian medics said. Injuries were also reported in Gaza after Israeli forces opened fire after protesters threw stones at Israeli army posts on the border.
Thousands of pro-Palestinian protesters held noisy demonstrations in Jordan, Egypt, Iraq, Turkey and Iran.
Further afield, protesters rallied in Malaysia, Bangladesh, Pakistan, Afghanistan, Indian-administered Kashmir and Indonesia, the world's largest Muslim-majority country.